antibiotic-loaded pmma bone cement simplex with tobramycin and gentamicin  (Stryker)

Journal: Antibiotics

Article Title: Strategies to Mitigate and Treat Orthopaedic Device-Associated Infections

doi: 10.3390/antibiotics11121822

Figure Lengend Snippet: Antimicrobial delivery systems based on PLA and PLGA coatings for metal implants. The table highlights polymer type, antibiotic/antiseptic, implant substrate, in vitro or in vivo model, release kinetics and experimental outcome.

Article Snippet: Several antibiotic-loaded PMMA bone cement products have been approved by the FDA, including Simplex with tobramycin and gentamicin (Stryker Howmedica Osteonics) [ ] and SmartSet GHV with gentamicin(DePuy Orthopaedics) [ , ].

Techniques: Polymer, In Vitro, In Vivo, Concentration Assay, Infection, Formulation, Control, Bacteria, Activity Assay

Journal: Antibiotics

Article Title: Strategies to Mitigate and Treat Orthopaedic Device-Associated Infections

doi: 10.3390/antibiotics11121822

Figure Lengend Snippet: SEM images of titania nanotubes (TNT) grown on Ti wire using the anodization technique. ( A ) The top surface showing cracks, ( B ) the entire structure showing TNT on Ti wire with dimensions, ( C ) the cross-section showing array of TNTs and ( D ) the hollow nanotubes. ( E ) Overall release and ( F ) burst release of gentamicin (corresponding to the first 6 h of fast diffusion of drug) from TNT-Ti wire. Modified and reproduced from CC BY 2.0 http://creativecommons.org/licenses/by/2.0 (accessed on 18 October 2022).

Article Snippet: Several antibiotic-loaded PMMA bone cement products have been approved by the FDA, including Simplex with tobramycin and gentamicin (Stryker Howmedica Osteonics) [ ] and SmartSet GHV with gentamicin(DePuy Orthopaedics) [ , ].

Techniques: Diffusion-based Assay, Modification